Incidence of atrial fibrillation in patients with central retinal artery occlusion: A Systematic Review and Meta-Analysis

Abstract Funding Acknowledgements Type of funding sources: None. Background Central retinal artery occlusion (CRAO) is a devastating event and atrial fibrillation (AF) recognized cause that may not be present at the time event. Purpose We performed meta-analysis for association CRAO with risk new-onset AF stroke during follow-up. Methods searched databases MEDLINE, Embase SCOPUS from inception to May 2022 terms ‘atrial fibrillation’ ‘retinal occlusion’ identified 205 studies. excluded duplicates, non-relevant studies those reporting after CRAO. used random effects models calculate pooled odds ratio (OR) 95% confidence intervals (CI) in patients or comparison control groups. Analysis was RevMan 5.4.1 (Cochrane 2020). Results included 7 1.476 compared group without (n=9.843) (n=7.058). There were 196 new cases (13.4%) 18 months associated higher (OR:1.59, CI:1.20-2.11, p=0.001) (OR:2.46, CI:1.74-3.47, p<0.001) when controls. However, similar (OR:0.83, CI:0.41-1.71, p=0.62). Conclusions stroke. though Thus, should regarded as cryptogenic mandate closer follow-up screening evaluation early anticoagulation.